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I received my undergraduate degree from a small private liberal arts college. During my undergraduate experience I was fortunate enough to have professors who cared about teaching and wanted us to excel at Biology. As an upperclassman I did research with one of the faculty members that resulted in a publication. The experiences and the professors I had as an undergraduate were what influenced me to become a Biology professor. I believe we here at Ozarks offer a quality education in the Biological Sciences that can lead directly to a job or professional school after graduation.

As a graduate student at the University of Iowa I had the opportunity to work with many excellent researchers. My immediate advisor, Dr. W. Scott Moye-Rowley, is interested in studying how eukaryotic cells deal with environmental stress (oxidative and drug). More particularly in my work we use the baker's yeast Saccharomyces cerevisiae as a model system for studying how eukaryotic cells deal with oxidative stress. Oxidative stress is when DNA, protein and/or lipid damage occur due to reactive oxygen species that are produced during normal eukaryotic cellular respiration. In other words cells produce dangerous molecules when they make energy, however, the cell also has a way to detoxify these dangerous oxygen species. We study the genes and their corresponding proteins involved in protecting cells from reactive oxygen species. This is studied in the hopes that this information can be used to combat the many diseases linked to oxidative stress including: certain cancers, Amyotrophic Lateral Sclerosis, Alzheimer's and Parkinson's.

Curriculum Vitae:

Sean Timothy Coleman Ph.D.

Education	1989 - 1991 Biology, University of Tampa Tampa, Florida 1992 - 1993 Biology, Luther College Decorah, Iowa B.A. Biology 1994 – 7/2000 Physiology and Biophysics, University of Iowa Ph.D. University of Iowa. Iowa City, Iowa
Research interest	Utilize Microbiology, Genetics and Molecular biology to study how eukaryotes deal with oxidative stress.
Current project	Using Saccharomyces cerevisiae as a model system to study the molecular mechanism of oxidative stress tolerance.
Teaching	1992 - 1993 Undergraduate teaching assistant in the Biology department at Luther College, Decorah, Iowa 1996 - 2000 Physiology (72:130) teaching assistant. University of Iowa, Iowa City, Iowa 1997 - 2000 Lectured in the 72:130 Physiology class including devising lectures, notes for students, giving lectures and generating exam questions. University of Iowa, Iowa City, Iowa 2000 – present Assistant Professor of Biology University of the Ozarks: Biochemistry, Biology Concepts, Cell Biology, Genetics and Microbiology.
Professional memberships	1996 - 1997 American Association for the Advancement of Science 1996 - 1998 American Society for Microbiology
Awards received	1997 - 1999 NIH/National Institute on Aging National Research Service Award (NRSA) predoctoral fellowship
Publications	Coleman S.T., Peterson G., Drähn D., Stolorov J., and K.W. Kraus (1995) A Drosophila accessory gland gene with similarity to serine protease inhibitors is transferred to females during mating. Insect Biochemistry and Molecular Biology 25 (2):203-207. Davisson R.L., Nuutinen N., Coleman S.T. and C.D. Sigmund. (1996) Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic Acids Research 24:4023-4028. Coleman S.T., Tseng E. and W.S. Moye-Rowley. (1997) The yAP-1 and Gcn4p regulatory networks converge at the ATR1 structural gene. The Journal of Biological Chemistry 272:23224-23230. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. (1999) Yap1p activates gene transcription in an oxidant specific fashion. Molecular and Cellular Biology 19(12):8302-8313. Zhang X., de Micheli M, Coleman S.T., Sanglard D and W.S. Moye-Rowley. (2000) Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p. Molecular Microbiology. 36(3):618-29. Coleman S.T., Fang T.K., Rovinsky S.A., Turano F. J. and W.S. Moye-Rowley. (2001). Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 276(1):244-50.
Abstracts	Coleman S.T., Peterson G., Drähn D., Stolorov J., and K.W. Kraus. (1993) A Drosophila accessory gland gene with similarity to serine protease inhibitors is transferred to females during mating", at the University of Minnesota 2nd annual symposium on Developmental Biology. Coleman S.T., Tseng E. and W.S. Moye-Rowley. (1996) YAP1-mediated transactivation of ATR1 confers resistance to the cytotoxic compounds 4-nitroquinoline-N-oxide and 3-amino-1,2,4-triazole. Yeast Genetics and Molecular Biology Meeting. Madison, WI. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. (1998) Molecular mechanism of eukaryotic oxidative stress tolerance. Genetics Society of America meeting. College Park, Maryland. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. (1999) Yap1p activates gene transcription in an oxidant specific fashion. College of Medicine Research Week. Iowa City, Iowa. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. (1999) Yap1p activates gene transcription in an oxidant specific fashion. Opportunity for Research in the Biomedical Sciences. Iowa City, Iowa. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. (2000) Yap1p activates gene transcription in an oxidant specific fashion International Yeast. Seattle, Washington.
Presentations	Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. Molecular mechanism of eukaryotic oxidative stress tolerance. Luther College. April 30, 1998. Decorah, Iowa. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. Yap1p activates gene transcription in an oxidant specific fashion. Physiology and Biophysics workshop. April 14, 1999. Iowa City, Iowa. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. Yap1p activates gene transcription in an oxidant specific fashion University of Iowa Center on Aging Seminar. April 22, 1999. Iowa City, Iowa. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. Yap1p activates gene transcription in an oxidant specific fashion Department of Biochemistry Seminar. September, 1999. Iowa City, Iowa. Coleman S.T., Epping E.A., Steggerda S.A. and W.S. Moye-Rowley. Yap1p activates gene transcription in an oxidant specific fashion International Yeast. July, 2000. Seattle, Washington.